Article
Evolution of the androgen receptor: structure-function implications.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Oct 1998
Thornton J W, Kelley D B
Abstract excerpt
To shed light on the nature and evolution of structure-function relations in the androgen receptor (AR), we have undertaken a comparative analysis of all available AR and other steroid receptor sequences. We have identified a group of amino acids that "diagnose" the clade of androgen receptors--r...
Topics
- Amino Acid Substitution
- Amphibians
- Animals
- Binding Sites
- DNA
- Evolution, Molecular
- Female
- Gene Expression Regulation
- Ligands
- Male
- Mammals
- Mutation
- Protein Conformation
- Receptors, Androgen
- Regulatory Sequences, Nucleic Acid
- Species Specificity
- Structure-Activity Relationship
- Testosterone