Article
[Identification of a highly conserved domain that suppresses the DNA-binding domain-DNA interactions in the androgen receptor].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 1 Aug 2005
Liu Guo-zhen, Wang Hua, Wang Zheng-xing
Abstract excerpt
OBJECTIVE: To determine the gene regulation of androgen receptor (AR). METHODS: Gel shift assay, protein-protein pull down assay, western blot and technique of site-directed mutagenesis were used to study the gene regulation of AR. RESULTS: The N terminal of AR contained an inhibitory domain located in an 81-amino acid segment lying upstream of the DNA-binding domain (DBD). The inhibitory domain interacted...
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