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Article

Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes.

Cancer science - 1 Jun 2024

Alanazi Mohammad, Weng Teresa, McLeod Louise, Gearing Linden J, Smith Julian A, Kumar Beena, Saad Mohamed I, Jenkins Brendan J

Abstract excerpt

Constitutively active KRAS mutations are among the major drivers of lung cancer, yet the identity of molecular co-operators of oncogenic KRAS in the lung remains ill-defined. The innate immune cytosolic DNA sensor and pattern recognition receptor (PRR) Absent-in-melanoma 2 (AIM2) is best known for its assembly of multiprotein inflammasome complexes and promoting an inflammatory response. Here, we define a role...

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Identifiers

PMID: 38594840
DOI: 10.1111/cas.16171
PMCID: PMC11145135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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