Article
Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity.
Blood - 1 Nov 1998
Grønbaek K, Straten P T, Ralfkiaer E, Ahrenkiel V, Andersen M K, Hansen N E, Zeuthen J, Hou-Jensen K, Guldberg P
Abstract excerpt
Fas (APO-1/CD95) is a cell-surface receptor involved in cell death signaling. Germline mutations in the Fas gene have been associated with autoimmune lymphoproliferative syndrome, and somatic Fas mutations have been found in multiple myeloma. We have examined the entire coding region and all spli...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Amino Acid Substitution
- Apoptosis
- Autoimmune Diseases
- Autoimmunity
- Codon
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Genetic Predisposition to Disease
- Humans
- Lymphoma, Non-Hodgkin
- Male
- Middle Aged
- Mutation, Missense