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Improving HLA typing imputation accuracy and eplet identification with local next-generation sequencing training data.

HLA - 1 Jan 2024

Lhotte Romain, Letort Véronique, Usureau Cédric, Jorge-Cordeiro Debora, Siemowski Jérémy, Gabet Lionel, Cournede Paul-Henry, Taupin Jean-Luc

Abstract excerpt

Assessing donor/recipient HLA compatibility at the eplet level requires second field DNA typings but these are not always available. These can be estimated from lower-resolution data either manually or with computational tools currently relying, at best, on data containing typing ambiguities. We gathered NGS typing data from 61,393 individuals in 17 French laboratories, for loci A, B, and C (100% of typings),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38589051
DOI: 10.1111/tan.15222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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