Differential gene expression in growth factors, epithelial mesenchymal transition and chemotaxis in the diffuse type compared with the intestinal type of gastric cancer

Abstract excerpt

Gastric cancer (GC) is a highly heterogeneous disease and one of the major causes of cancer‑related mortality worldwide. Diffuse‑type gastric adenocarcinoma (or poorly cohesive‑ with independent cells) is characterized by aggressive behavior (rapid invasion, chemoresistance and peritoneal metastasis), as compared with intestinal‑subtype adenocarcinoma. Diffuse subtype GC additionally has a substantially...

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