Article
Effects of S-adenosylmethionine on AfsKRS regulation in pristinamycin biosynthesis in Streptomyces pristinaespiralis.
The Journal of general and applied microbiology - 4 Sept 2024
Liu Yan, Shen Na, Wu Zhige, Yang Yu, Dong Xinyan, Jin Zhihua, Jin Qingchao
Abstract excerpt
In Streptomyces pristinaespiralis, AfsKRS system has differential regulation for PI and PII component biosynthesis of pristinamycin, but it is unknown whether S-adenosylmethionine (SAM) plays an important role in the AfsK-AfsR-AfsS signal transduction cascade during pristinamycin production. The possible target of exogenous SAM in the AfsKRS system and the biological role of SAM during the production of PI and...
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