Article
S-adenosyl-L-methionine activates actinorhodin biosynthesis by increasing autophosphorylation of the Ser/Thr protein kinase AfsK in Streptomyces coelicolor A3(2).
Bioscience, biotechnology, and biochemistry - 1 Jan 2011
Jin Ying-Yu, Cheng Jinhua, Yang Seung Hwan, Meng Lingzhu, Palaniyandi Sasikumar Arunachalam, Zhao Xin-Qing, Suh Joo-Won
Abstract excerpt
S-Adenosyl-L-methionine (SAM) is one of the major methyl donors in all living organisms. The exogenous treatment with SAM leads to increased actinorhodin production in Streptomyces coelicolor A3(2). In this study, mutants from different stages of the AfsK-AfsR signal transduction cascade were used to test the possible target of SAM. SAM had no significant effect on actinorhodin production in afsK, afsR, afsS, or...
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