Article
The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova.
Nature communications - 5 Apr 2024
Chitwood Melanie H, Colijn Caroline, Yang Chongguang, Crudu Valeriu, Ciobanu Nelly, Codreanu Alexandru, Kim Jaehee, Rancu Isabel, Rhee Kyu, Cohen Ted, Sobkowiak Benjamin
Abstract excerpt
The projected trajectory of multidrug resistant tuberculosis (MDR-TB) epidemics depends on the reproductive fitness of circulating strains of MDR M. tuberculosis (Mtb). Previous efforts to characterize the fitness of MDR Mtb have found that Mtb strains of the Beijing sublineage (Lineage 2.2.1) may be more prone to develop resistance and retain fitness in the presence of resistance-conferring mutations than other...
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