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Improved integration of single-cell transcriptome data demonstrates common and unique signatures of heart failure in mice and humans

1 Jan 2024

Abstract excerpt

BACKGROUND: Cardiovascular research heavily relies on mouse (Mus musculus) models to study disease mechanisms and to test novel biomarkers and medications. Yet, applying these results to patients remains a major challenge and often results in noneffective drugs. Therefore, it is an open challenge of translational science to develop models with high similarities and predictive value. This requires a comparison of...

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Share to Cardiac Fibrosis and Remodeling
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PMID: 38573186
DOI: 10.1093/gigascience/giae011

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