Interpretation of murine models of cardiac disease is enhanced by consideration of divergently expressed human-mouse orthologous genes

Abstract excerpt

Humans and mice share remarkably similar cardiac anatomy and physiology and have many orthologous genes with high sequence similarity. Together with their small size and short lifespan, these factors are major contributors to the popularity of mice as research models. Nonetheless, findings in mice often fail to translate into humans. We propose that this may be due in part to differences in gene expression. Advanc...

Topics

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• Arrhythmias, Cardiac
• Atherosclerosis and Cardiovascular Diseases
• Cardiac Fibrosis and Remodeling
• Heterozygote
• Homozygote
• Mice
• Mice, Knockout
• Phenotype

Identifiers and source

Literature Corpus work

aa3c0c9a-d28a-59ba-aa92-a34be6b74c22

DOI

10.1101/2024.06.15.599153