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CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly

3 Apr 2024

Abstract excerpt

The immune system substantially influences age-related cognitive decline and Alzheimer’s disease (AD) progression, affected by genetic and environmental factors. In a Mayo Clinic Study of Aging cohort, we examined how risk factors like APOE genotype, age, and sex affect inflammatory molecules and AD biomarkers in cerebrospinal fluid (CSF). Among cognitively unimpaired individuals over 65 ( N = 298), we measured...

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PMID: 38569027
DOI: 10.1126/sciadv.adk3674

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