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Article

Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer's Disease Pathology and Neuronal Damage.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Bettcher Brianne M, Johnson Sterling C, Fitch Ryan, Casaletto Kaitlin B, Heffernan Kate S, Asthana Sanjay, Zetterberg Henrik, Blennow Kaj, Carlsson Cynthia M, Neuhaus John, Bendlin Barbara B, Kramer Joel H

Abstract excerpt

Inflammatory markers have been shown to predict neurocognitive outcomes in aging adults; however, the degree to which peripheral markers mirror the central nervous system remains unknown. We investigated the association between plasma and cerebrospinal fluid (CSF) markers of inflammation, and explored whether these markers independently predict CSF indicators of Alzheimer's disease (AD) pathology or neuronal...

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PMID: 29439331
DOI: 10.3233/JAD-170602
PMCID: PMC6007886

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