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Article

A Hypermutable Region in the DISP2 Gene Links to Natural Selection and Late-Onset Neurocognitive Disorders in Humans.

Molecular neurobiology - 1 Nov 2024

Khamse S, Alizadeh S, Khorshid H R Khorram, Delbari A, Tajeddin N, Ohadi M

Abstract excerpt

(CCG) short tandem repeats (STRs) are predominantly enriched in genic regions, mutation hotspots for C to T truncating substitutions, and involved in various neurological and neurodevelopmental disorders. However, intact blocks of this class of STRs are widely overlooked with respect to their link with natural selection. The human neuron-specific gene, DISP2 (dispatched RND transporter family member 2), contains...

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Age of Onset
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Alleles
Genotype
Microsatellite Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurocognitive Disorders

Selection, Genetic

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PMID: 38565786
DOI: 10.1007/s12035-024-04155-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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