Article
Nonsense-mediated decay of alternative precursor mRNA splicing variants is a major determinant of the Arabidopsis steady state transcriptome.
The Plant cell - 1 Oct 2013
Drechsel Gabriele, Kahles André, Kesarwani Anil K, Stauffer Eva, Behr Jonas, Drewe Philipp, Rätsch Gunnar, Wachter Andreas
Abstract excerpt
The nonsense-mediated decay (NMD) surveillance pathway can recognize erroneous transcripts and physiological mRNAs, such as precursor mRNA alternative splicing (AS) variants. Currently, information on the global extent of coupled AS and NMD remains scarce and even absent for any plant species. To address this, we conducted transcriptome-wide splicing studies using Arabidopsis thaliana mutants in the NMD factor...
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