Article
Targeting ferroptosis in gastrointestinal tumors: Interplay of iron-dependent cell death and autophagy
24 Jan 2025
Abstract excerpt
Ferroptosis is a regulated cell death mechanism distinct from apoptosis, autophagy, and necroptosis, marked by iron accumulation and lipid peroxidation. Since its identification in 2012, it has developed into a potential therapeutic target, especially concerning GI disorders like PC, HCC, GC, and CRC. This interest arises from the distinctive role of ferroptosis in the progression of diseases, presenting a new...
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