Article
The role of age at menarche and age at menopause in Alzheimer's disease: evidence from a bidirectional mendelian randomization study.
Aging - 4 Aug 2021
Li Mingli, Lin Jiali, Liang Shuang, Chen Zefeng, Bai Yulan, Long Xinyang, Huang Shengzhu, Mo Zengnan
Abstract excerpt
The association between endogenous estrogen exposure and Alzheimer's disease (AD) remains inconclusive in previous observational studies, and few Mendelian randomization (MR) studies have focused on their causality thus far. We performed a bidirectional MR study to clarify the causality and causal direction of age at menarche and age at menopause, which are indicators of endogenous estrogen exposure, on AD risk....
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