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Article

TP53 mutations and the association with platinum resistance in high grade serous ovarian carcinoma.

Gynecologic oncology - 1 Jul 2024

Montemorano Lauren, Shultz Zoey B, Farooque Alma, Hyun Meredith, Chappell Richard J, Hartenbach Ellen M, Lang Jessica D

Abstract excerpt

OBJECTIVES: Alterations in the tumor suppressor TP53 gene are the most common mutations in high grade serous ovarian carcinoma. The impact of TP53 mutations on clinical outcomes and platinum resistance is controversial. We sought to evaluate the genomic profile of high grade serous ovarian carcinoma and explore the association of TP53 mutations with platinum resistance. METHODS: Next generation sequencing data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38555766
DOI: 10.1016/j.ygyno.2024.03.023
PMCID: PMC11216889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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