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Article

Spectrum of TP53 Mutations in BRCA1/2 Associated High-Grade Serous Ovarian Cancer

16 Jul 2020

Abstract excerpt

Objective: Mutations in TP53 lead to loss of function or gain of function (GOF) of the corresponding protein, p53, and have a different effect on the tumor. We aimed to determine the spectrum of TP53 mutations in BRCA1/2 associated serous ovarian cancer (HGSOC). Methods: The study population comprised of HGSOCs with mutations in BRCA1 (78) or BRCA2 (21). Only chemo-naive and platinum-sensitive patients were...

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PMID: 32766142
DOI: 10.3389/fonc.2020.01103

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