Reduced Expression of Cytoskeletal and Extracellular Matrix Genes in Human Adult Retinal Pigment Epithelium Cells Exposed to Simulated Microgravity.

doi:10.1159/000452520

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Article

Reduced Expression of Cytoskeletal and Extracellular Matrix Genes in Human Adult Retinal Pigment Epithelium Cells Exposed to Simulated Microgravity.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2016

Corydon Thomas J, Mann Vivek, Slumstrup Lasse, Kopp Sascha, Sahana Jayashree, Askou Anne Louise, Magnusson Nils E, Echegoyen David, Bek Toke, Sundaresan Alamelu, Riwaldt Stefan, Bauer Johann, Infanger Manfred, Grimm Daniela

Abstract excerpt

BACKGROUND/AIMS: Microgravity (µg) has adverse effects on the eye of humans in space. The risk of visual impairment is therefore one of the leading health concerns for NASA. The impact of µg on human adult retinal epithelium (ARPE-19) cells is unknown. METHODS: In this study we investigated the influence of simulated µg (s-µg; 5 and 10 days (d)), using a Random Positioning Machine (RPM), on ARPE-19 cells. We...

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PMID: 27842307
DOI: 10.1159/000452520

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