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Article

Solid Organ Transplant Recipients Exhibit More TET2-Mutant Clonal Hematopoiesis of Indeterminate Potential Not Driven by Increased Transplantation Risk.

Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Jun 2024

Silver Alexander J, Vlasschaert Caitlyn, Mack Taralynn, Sharber Brian, Xu Yaomin, Bick Alexander G, Pinson C Wright, Savona Michael R

Abstract excerpt

PURPOSE: Solid organ transplant recipients comprise a unique population of immunosuppressed patients with increased risk of malignancy, including hematologic neoplasms. Clonal hematopoiesis of indeterminate potential (CHIP) represents a known risk factor for hematologic malignancy and this study describes the prevalence and patterns of CHIP mutations across several types of solid organ transplants. EXPERIMENTAL...

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PMID: 38551504
DOI: 10.1158/1078-0432.CCR-23-3840

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