Article
Application of prime editing system to introduce TP53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line.
Cancer science - 1 Jun 2024
Nguyen Thao, Aida Tomomi, Iijima-Yamashita Yuka, Tamai Minori, Nagamachi Akiko, Kagami Keiko, Komatsu Chiaki, Kasai Shin, Akahane Koshi, Goi Kumiko, Inaba Toshiya, Sanada Masashi, Inukai Takeshi
Abstract excerpt
In childhood acute lymphoblastic leukemia (ALL), TP53 gene mutation is associated with chemoresistance in a certain population of relapsed cases. To directly verify the association of TP53 gene mutation with chemoresistance of relapsed childhood ALL cases and improve their prognosis, the development of appropriate human leukemia models having TP53 mutation in the intrinsic gene is required. Here, we sought to...
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