Article

Cellular Genome-scale Metabolic Modeling Identifies New Potential Drug Targets Against Hepatocellular Carcinoma

2021-12-06

Abstract excerpt

Hepatocellular carcinoma is the third leading cause of cancer related mortality worldwide. Often this hepatic cancer is associated with fatty liver disease and insulin resistance with genetic predisposition are its major driver. Genome-scale metabolic modeling (GEM) is a promising approach to understand cancer metabolism and to identify new drug targets. Here, we used TRFBA-CORE, an algorithm generating a model us...

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Literature Corpus work: cc6dc1fc-6428-52f1-9b1d-3f55ccf6d469
DOI: 10.21203/rs.3.rs-1120182/v1

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