Article
Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Jun 2024
Wu Han, Ding Miao, Zhu Jiabei, Mao Siwei, Tang Xiaochen, Fang Sijia, Liu Li, Pan Qiuhui, Yue Chaoyan
Abstract excerpt
BACKGROUND: The causal relationship between sex hormone-binding globulin (SHBG) and neuroblastoma remains unknown. This study aimed to explore the causality between SHBG and the risk of neuroblastoma using bidirectional two-sample Mendelian randomization (MR) study. METHODS: Instrumental variables associated with SHBG were obtained from the genome-wide association study (GWAS) of European containing 214,989...
Topics
- Female
- Humans
- Male
- Genome-Wide Association Study
- Mendelian Randomization Analysis
- Neuroblastoma
- Polymorphism, Single Nucleotide
- Risk Factors
- Sex Hormone-Binding Globulin