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Article

TERT Gene Fusions Characterize a Subset of Metastatic Leydig Cell Tumors

21 Feb 2021

Abstract excerpt

OBJECTIVE: Metastatic Leydig cell tumors (LCT) are rare, difficult-to-treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic profiling for detection of therapeutic targets, which was then followed by an investigation into a cohort of additional LCTs. PATIENTS AND METHODS: Twenty-nine LCT (27 male and 2 female...

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PMID: 33741265
DOI: 10.1016/j.clgc.2021.02.002

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