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Article

GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer.

Molecular cancer research : MCR - 1 Jan 2022

Burleson Marieke, Deng Janice J, Qin Tai, Duong Thu Minh, Yan Yuqian, Gu Xiang, Das Debodipta, Easley Acarizia, Liss Michael A, Yew P Renee, Bedolla Roble, Kumar Addanki Pratap, Huang Tim Hui-Ming, Zou Yi, Chen Yidong, Chen Chun-Liang, Huang Haojie, Sun Lu-Zhe, Boyer Thomas G

Abstract excerpt

Although the Sonic hedgehog (SHH) signaling pathway has been implicated in promoting malignant phenotypes of prostate cancer, details on how it is activated and exerts its oncogenic role during prostate cancer development and progression is less clear. Here, we show that GLI3, a key SHH pathway effector, is transcriptionally upregulated during androgen deprivation and posttranslationally stabilized in prostate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34610962
DOI: 10.1158/1541-7786.MCR-21-0108
PMCID: PMC9258906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer.PMID 34610962Read ↗

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