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Article

Modulation of Androgen Receptor by FOXA1 and FOXO1 Factors in Prostate Cancer

1 Jan 2014

Abstract excerpt

Androgens and the androgen receptor (AR) are essential for growth and differentiation of the normal prostate gland as well as proliferation and survival of prostate cancer (PCa). Increasing evidence suggests that reactivation of the AR plays a pivotal role in disease progression to castration-resistant PCa (CRPC). Forkhead box (FOX) factors exert two distinct effects on AR function in PCa. The A-class of FOX...

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Identifiers

PMID: 24948874
DOI: 10.7150/ijbs.8389

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