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Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomes

2022-09-07

Abstract excerpt

<h4>Objective: </h4> This study aims to demonstrate the cellular composition and underlying mechanisms in subchondral bone marrow lesions (BMLs) of knee osteoarthritis (OA). Methods BMLs were accessed by MRI Osteoarthritis Knee Score (MOAKS) ≥ 2. Bulk RNA-sequencing (bulk-seq) and BML-specific differentially expressed genes (DEGs) analysis were performed among subchondral bone samples (including OA-BML = 3, paire...

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Literature Corpus work
58c8f81e-346a-5bf4-bbe2-5bf121eb1c94
DOI
10.21203/rs.3.rs-2015908/v1
Open publication

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Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomesDOI 10.21203/rs.3.rs-2015908/v1
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