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Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis

7 Oct 2024

Abstract excerpt

OBJECTIVES: In this study, we employ a multiomic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine differences in the IFP based on knee osteoarthritis (KOA), sex and obesity status. METHODS: Single-nucleus RNA sequencing of 82 924 nuclei from 21 IFPs (n=6 healthy control and n=15 KOA donors), spatial transcriptomics and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39375009
DOI: 10.1136/ard-2024-225928

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