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The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease.

Laboratory medicine - 4 Sept 2024

Navari Mahsa, Zarei Fatemeh, Sayedsalehi Shiva, Mahmoudi Touraj, Rostami Mitra, Mahban Aidin, Rezamand Gholamreza, Asadi Asadollah, Dabiri Reza, Nobakht Hossein, Farahani Hamid, Tabaeian Seidamir Pasha, Zali Mohammad Reza

Abstract excerpt

BACKGROUND: Given that obesity and insulin resistance play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the connection between leptin and these metabolic diseases, the association between NAFLD and a leptin receptor gene (LEPR) polymorphism was examined. METHODS: In this genetic case-control association study, 144 biopsy-proven NAFLD patients and 144 controls were genotyped for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 38522074
DOI: 10.1093/labmed/lmae016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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