Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene.

Journal of gastroenterology and hepatology - 1 May 2013

Zain Shamsul Mohd, Mohamed Zahurin, Mahadeva Sanjiv, Cheah Phaik-Leng, Rampal Sanjay, Chin Kin-Fah, Mahfudz Anis Shafina, Basu Roma Choudhury, Tan Hwa-Li, Mohamed Rosmawati

Abstract excerpt

BACKGROUND AND AIM: Genetic polymorphism has been implicated as a factor for the occurrence of non-alcoholic fatty liver disease (NAFLD). This study attempted to assess whether polymorphisms in the leptin receptor (LEPR) gene and its combined effect with patatin-like phospholipase domain-containing protein 3 (PNPLA3/adiponutrin) are associated with risk of NAFLD. METHODS: A total of 144 biopsy-proven NAFLD and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Susceptibility
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Liver

Share to Membrane Proteins

Share to Non-alcoholic Fatty Liver Disease

Share to Receptors, Leptin

Source

Identifiers

PMID: 23278404
DOI: 10.1111/jgh.12104

Genes

LEPR
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene.PMID 23278404Read ↗

Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor.Semantic proximity Read ↗

Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China.Semantic proximity Read ↗

Interactions of allelic variance of PNPLA3 with nongenetic factors in predicting nonalcoholic steatohepatitis and nonhepatic complications of severe obesity.Semantic proximity Read ↗

Update on nonalcoholic fatty liver disease: genes involved in nonalcoholic fatty liver disease and associated inflammation.Semantic proximity Read ↗

Lys656Asn polymorphism of leptin receptor, leptin levels and insulin resistance in patients with non alcoholic fatty liver disease.Semantic proximity Read ↗

[Influence of leptin receptor gene K109R polymorphism on the risk of nonalcoholic fatty liver disease and its interaction with PNPLA3 I148M polymorphism].Semantic proximity Read ↗

The association of nonalcoholic fatty liver disease with genetic polymorphisms: a multicenter study.Semantic proximity Read ↗

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults.Semantic proximity Read ↗

Association Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-AnalysisSemantic proximity Read ↗

Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Characteristics of non‐obese non‐alcoholic fatty liver disease: Effect of genetic and environmental factorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.