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Article

The LEPR K109R and Q223R Might Contribute to the Risk of NAFLD: A Meta-Analysis.

Current molecular medicine - 1 Jan 2018

Pan X, Zheng M, Zou T, Liu W, Gu X, Zhang X, Cheng X

Abstract excerpt

BACKGROUND: Leptin and insulin resistance have been pointed out to play a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Increasing genes were shown to be associated with the risk of NAFLD. OBJECTIVE: The study aimed to investigate the genetic association between two leptin receptor (LEPR) polymorphisms (Q223R and K109R) and the NAFLD risk. METHODS: Studies were retrieved and included by...

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Source

Identifiers

PMID: 29974828
DOI: 10.2174/1566524018666180705110412

Genes

LEPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The LEPR K109R and Q223R Might Contribute to the Risk of NAFLD: A Meta-Analysis.PMID 29974828Read ↗

[Influence of leptin receptor gene K109R polymorphism on the risk of nonalcoholic fatty liver disease and its interaction with PNPLA3 I148M polymorphism].Semantic proximity Read ↗

A meta-analysis of associations of LEPR Q223R and K109R polymorphisms with Type 2 diabetes risk.Semantic proximity Read ↗

Leptin receptor Gln223Arg and Lys109Arg polymorphisms may be associated with HBV-related hepatocellular carcinoma risk: A system review and meta-analysis.Semantic proximity Read ↗

Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China.Semantic proximity Read ↗

Lys656Asn polymorphism of leptin receptor, leptin levels and insulin resistance in patients with non alcoholic fatty liver disease.Semantic proximity Read ↗

The Inter-Relation between Leptin Receptor (Q223R) Gene Polymorphism and the Risk of Egyptian Patients with HCC.Semantic proximity Read ↗

Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis.Semantic proximity Read ↗

The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease.Semantic proximity Read ↗

Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD.Semantic proximity Read ↗

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Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene.Semantic proximity Read ↗

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