Article
Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate.
Cancer research communications - 3 Apr 2024
Hirani Priyanka, McDermott Jacqueline, Rajeeve Vinothini, Cutillas Pedro R, Jones J Louise, Pennington Daniel J, Wight Thomas N, Santamaria Salvatore, Alonge Kimberly M, Pearce Oliver M T
Abstract excerpt
Immunotherapies for cancers of epithelial origin have limited efficacy, and a growing body of evidence links the composition of extracellular matrix (ECM) with the likelihood of a favorable response to treatment. The ECM may be considered an immunologic barrier, restricting the localization of cytotoxic immune cells to stromal areas and inhibiting their contact with tumor cells. Identifying ECM components of this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.