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Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

21 Mar 2024

Abstract excerpt

Abstract Aims/hypothesis Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly connected ‘hub’ cells, important for the propagation of intercellular Ca 2+ waves. Functional subpopulations have also been demonstrated in human beta cells, with...

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PMID: 38512414
DOI: 10.1007/s00125-024-06123-6

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