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Article

Structural diversity of Burkholderia pseudomallei lipopolysaccharides affects innate immune signaling

28 Apr 2017

Abstract excerpt

Burkholderia pseudomallei (Bp) causes the disease melioidosis.The main cause of mortality in this disease is septic shock triggered by the host responding to lipopolysaccharide (LPS) components of the Gram-negative outer membrane.Bp LPS is thought to be a weak inducer of the host immune system.LPS from several strains of Bp were purified and their ability to induce the inflammatory mediators TNF-α and iNOS in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28453531
DOI: 10.1371/journal.pntd.0005571

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