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Article

Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix.

The Journal of biological chemistry - 25 Aug 2006

Andreotti Giuseppina, Méndez Blanca López, Amodeo Pietro, Morelli Maria A Castiglione, Nakamuta Hiromichi, Motta Andrea

Abstract excerpt

Salmon calcitonin (sCT) forms an amphipathic helix in the region 9-19, with the C-terminal decapeptide interacting with the helix (Amodeo, P., Motta, A., Strazzullo, G., Castiglione Morelli, M. A. (1999) J. Biomol. NMR 13, 161-174). To uncover the structural requirements for the hormone bioactivity, we investigated several sCT analogs. They were designed so as to alter the length of the central helix by removal...

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PMID: 16766525
DOI: 10.1074/jbc.M603528200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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