Diverse specificities, phenotypes, and antiviral activities of cytomegalovirus-specific CD8+ T cells.

Abstract excerpt

UNLABELLED: CD8(+) T cells specific for pp65, IE1, and IE2 are present at high frequencies in human cytomegalovirus (HCMV)-seropositive individuals, and these have been shown to have phenotypes associated with terminal differentiation, as well as both cytokine and proliferative dysfunctions, especially in the elderly. However, more recently, T cell responses to many other HCMV proteins have been described, but...

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• Cohort Studies
• Aged, 80 and over
• CD8-Positive T-Lymphocytes
• Cytomegalovirus
• Cytomegalovirus Infections