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Article

Development of New PCR Protocols to Detect Genetic Diversity in the Metronidazole Metabolism Genes in Susceptible and Refractory Clinical Samples of Giardia duodenalis.

Acta parasitologica - 1 Mar 2024

Asghari Ali, Mahdavi Farzad, Yousefi Amirhosein, Shamsi Laya, Badali Roya, Mohammadi Mohammad Reza, Irannejad Hamid, Mohammadi-Ghalehbin Behnam, Shahabi Saeed, Asgari Qasem, Motazedian Mohammad Hossein, Bastaminejad Saiyad

Abstract excerpt

PURPOSE: Investigating the genetic variation in thioredoxin reductase (TrxR) and nitroreductase (NR) genes in both treatment-resistant and -sensitive Giardia duodenalis isolates can provide valuable information in identifying potential markers of resistance to metronidazole. The rapid increase in metronidazole treatment failures suggests the presence of genetic resistance mechanisms. By analyzing these genes,...

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PMID: 38499920
DOI: 10.1007/s11686-024-00828-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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