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Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis

13 Mar 2018

Abstract excerpt

Background: Metronidazole (Mtz) is the frontline drug treatment for multiple anaerobic pathogens, including the gastrointestinal protist, Giardia duodenalis. However, treatment failure is common and linked to in vivo drug resistance. In Giardia, in vitro drug-resistant lines allow controlled experimental interrogation of resistance mechanisms in isogenic cultures. However, resistance-associated changes are...

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PMID: 29688452
DOI: 10.1093/gigascience/giy024

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