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Article

A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics.

British journal of clinical pharmacology - 1 Jan 2023

Lehtisalo Minna, Taskinen Suvi, Tarkiainen E Katriina, Neuvonen Mikko, Viinamäki Jenni, Paile-Hyvärinen Maria, Lilius Tuomas O, Tapaninen Tuija, Backman Janne T, Tornio Aleksi, Niemi Mikko

Abstract excerpt

AIMS: The aim was to comprehensively investigate the effects of genetic variability on the pharmacokinetics of rosuvastatin. METHODS: We conducted a genome-wide association study and candidate gene analyses of single dose rosuvastatin pharmacokinetics in a prospective study (n = 159) and a cohort of previously published studies (n = 88). RESULTS: In a genome-wide association meta-analysis of the prospective study...

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Identifiers

PMID: 35942816
DOI: 10.1111/bcp.15485
PMCID: PMC10087178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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