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Article

MLL1 regulates cytokine-driven cell migration and metastasis

13 Mar 2024

Abstract excerpt

Cell migration is a critical contributor to metastasis. Cytokine production and its role in cancer cell migration have been traditionally associated with immune cells. We find that the histone methyltransferase Mixed-Lineage Leukemia 1 (MLL1) controls 3D cell migration via cytokines, IL-6, IL-8, and TGF-β1, secreted by the cancer cells themselves. MLL1, with its scaffold protein Menin, controls actin filament...

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PMID: 38478601
DOI: 10.1126/sciadv.adk0785

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