Article
Genetic Risk of Diverticular Disease Predicts Early Stoppage of Nicorandil.
Clinical pharmacology and therapeutics - 1 Dec 2020
Noyes James D, Mordi Ify R, Doney Alexander S, Palmer Colin N A, Pearson Ewan R, Lang Chim C
Abstract excerpt
Gastrointestinal fistulation has been widely reported as an adverse effect of nicorandil therapy in Europe. People who have underlying diverticular disease are most at risk of this side effect. In Western countries, diverticular disease is highly prevalent and can be clinically silent. This study aimed to identify diverticular disease genetic risk scores (GRSs) associated with early nicorandil stoppage, a...
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