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Article

Influence of Genetic Variation in COMT on Cisplatin-Induced Nephrotoxicity in Cancer Patients.

Genes - 27 Mar 2020

Agema Bram C, Koolen Stijn L W, With Mirjam de, Doorn Nadia van, Heersche Niels, Hoop Esther Oomen-de, Visser Sabine, Aerts Joachim G J V, Bins Sander, Schaik Ron H N van, Mathijssen Ron H J

Abstract excerpt

Cisplatin is a chemotherapeutic agent widely used for multiple indications. Unfortunately, in a substantial set of patients treated with cisplatin, dose-limiting acute kidney injury (AKI) occurs. Here, we assessed the association of 3 catechol-O-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) with increased cisplatin-induced nephrotoxicity. In total, 551 patients were genotyped for the 1947 G>A...

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Identifiers

PMID: 32230800
DOI: 10.3390/genes11040358
PMCID: PMC7230333

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