Article
Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy.
PloS one - 1 Jan 2015
Van Driest Sara L, McGregor Tracy L, Velez Edwards Digna R, Saville Ben R, Kitchner Terrie E, Hebbring Scott J, Brilliant Murray, Jouni Hayan, Kullo Iftikhar J, Creech C Buddy, Kannankeril Prince J, Vear Susan I, Brothers Kyle B, Bowton Erica A, Shaffer Christian M, Patel Neelam, Delaney Jessica T, Bradford Yuki, Wilson Sarah, Olson Lana M, Crawford Dana C, Potts Amy L, Ho Richard H, Roden Dan M, Denny Josh C
Abstract excerpt
Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and concurrent nephrotoxic medications fail to accurately predict nephrotoxicity. To identify potential genomic risk factors, we performed a genome-wide association study (GWAS) of serum creatinine levels while on vancomycin in 489 European American individuals and...
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