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[Tobacco etch virus proteinase: crystal structure of the active enzyme and its inactive mutant].

Bioorganicheskaia khimiia - 1 Jan 2000

Zhdanov A S, Phan J, Evdokimov A G, Tropea J E, Kapust R B, Li M, Wlodawer A, Waugh D S

Abstract excerpt

Tobacco Etch Virus Protease (TEV protease) is widely used as a tool for separation of recombinant target proteins from their fusion partners. The crystal structures of two mutants of TEV protease, active autolysis-resistant mutant TEV-S219D in complex with the proteolysis product, and inactive mutant TEV-C151A in complex with a substrate, have been determined at 1.8 and 2.2 A resolution, respectively. The active...

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PMID: 14601399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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