Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of Carbonic Anhydrase 2 Overcomes Temozolomide Resistance in Glioblastoma Cells

23 Dec 2021

Abstract excerpt

About 95% of Glioblastoma (GBM) patients experience tumor relapse as a consequence of resistance to the first-line standard chemotherapy using temozolomide (TMZ). Recent studies reported consistently elevated expression levels of carbonic anhydrase CA2 in recurrent glioblastoma and temozolomide-resistant glioblastoma stem-like cells (GSCs). Here we show that CA2 is preferentially expressed in GSCs and upregulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholinesterase and Neurodegenerative Diseases
Share to Enzyme function and inhibition
Share to Ion channel regulation and function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35008590
DOI: 10.3390/ijms23010157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Carbonic Anhydrase 2 Overcomes Temozolomide Resistance in Glioblastoma CellsPMID 35008590Read ↗

Carbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor CellsSemantic proximity Read ↗

Carbonic Anhydrase IX Inhibitors as Candidates for Combination Therapy of Solid TumorsSemantic proximity Read ↗

Metabolic Vulnerabilities of Temozolomide-Resistant Glioblastoma Cells: Implications for Targeted Therapies and Overcoming ChemoresistanceSemantic proximity Read ↗

Cancer-Associated Carbonic Anhydrases and Their InhibitionSemantic proximity Read ↗

Association between SOX9 and CA9 in glioma, and its effects on chemosensitivity to TMZSemantic proximity Read ↗

Alterations in Cell Motility, Proliferation, and Metabolism in Novel Models of Acquired Temozolomide Resistant GlioblastomaSemantic proximity Read ↗

Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Semantic proximity Read ↗

Vacuolar Proton-Translocating ATPase May Take Part in the Drug Resistance Phenotype of Glioma Stem Cells.Semantic proximity Read ↗

Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxiaSemantic proximity Read ↗

V-ATPase Proton Pump May Take Part to Drug-Resistance Phenotype of Glioma Stem CellsSemantic proximity Read ↗

Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma CellsSemantic proximity Read ↗

Colorectal adenocarcinomas downregulate the mitochondrial Na <sup>+</sup> /Ca <sup>2+</sup> exchanger NCLX to drive metastatic spreadSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.