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Article

Pluripotent Stem Cells as a Preclinical Cellular Model for Studying Hereditary Spastic Paraplegias.

International journal of molecular sciences - 23 Feb 2024

Damiani Devid, Baggiani Matteo, Della Vecchia Stefania, Naef Valentina, Santorelli Filippo Maria

Abstract excerpt

Hereditary spastic paraplegias (HSPs) comprise a family of degenerative diseases mostly hitting descending axons of corticospinal neurons. Depending on the gene and mutation involved, the disease could present as a pure form with limb spasticity, or a complex form associated with cerebellar and/or cortical signs such as ataxia, dysarthria, epilepsy, and intellectual disability. The progressive nature of HSPs...

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Identifiers

PMID: 38473862
DOI: 10.3390/ijms25052615
PMCID: PMC10932093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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