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Modeling Axonal Phenotypes with Human Pluripotent Stem Cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Denton Kyle R, Xu Chong-Chong, Li Xue-Jun

Abstract excerpt

Impaired axonal development and degeneration are implicated in many debilitating disorders, such as hereditary spastic paraplegia (HSP), amyotrophic lateral sclerosis (ALS), and periphery neuropathy. Human pluripotent stem cells (hPSCs) have provided researchers with an excellent resource for modeling human neuropathologic processes including axonal defects in vitro. There are a number of steps that are crucial...

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PMID: 25520289
DOI: 10.1007/7651_2014_167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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