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Article

A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs.

PLoS genetics - 1 Mar 2024

Perlmutter Jessamyn I, Chapman Joanne R, Wilkinson Mason C, Nevarez-Saenz Isaac, Unckless Robert L

Abstract excerpt

Antimicrobial peptides (AMPs) are at the interface of interactions between hosts and microbes and are therefore expected to be rapidly evolving in a coevolutionary arms race with pathogens. In contrast, previous work demonstrated that insect AMPs tend to evolve more slowly than the genome average. Metchikowin (Mtk) is a Drosophila AMP that has a single amino acid residue that segregates as either proline (P) or...

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PMID: 38466751
DOI: 10.1371/journal.pgen.1011155
PMCID: PMC10957085

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