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Article

Associations of ADH1B and ALDH2 genotypes and alcohol flushing with drinking history, withdrawal symptoms, and ICD-10 criteria in Japanese alcohol-dependent men.

Pharmacogenetics and genomics - 1 Jul 2024

Yokoyama Akira, Yokoyama Tetsuji, Yumoto Yosuke, Takimura Tsuyoshi, Toyama Tomomi, Yoneda Junichi, Nishimura Kotaro, Minobe Ruriko, Matsuzaki Takanobu, Kimura Mitsuru, Matsushita Sachio

Abstract excerpt

OBJECTIVES: Given the high prevalence of fast-metabolizing alcohol dehydrogenase-1B*2 (ADH1B*2 ) and inactive aldehyde dehydrogenase-2*2 (ALDH2*2 ) alleles in East Asians, we evaluated how the ADH1B / ALDH2 genotypes and alcohol flushing might affect the development of alcohol dependence (AD). METHODS: We evaluated how the ADH1B / ALDH2 genotypes and self-reported alcohol flushing affected history of drinking...

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Source

Identifiers

PMID: 38465575
DOI: 10.1097/FPC.0000000000000528

Genes

ADH1B
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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